23 Apr 2010

BECT(Benign epilepsy of childhood with centro-temporal spikes)の子どもにおける睡眠:NREM sleep instability in benign childhood epilepsy with centro-temporal spikes

Reduced NREM sleep instability in benign childhood... [Clin Neurophysiol. 2010] 
http://www.ncbi.nlm.nih.gov/pubmed/20097604
  • Sleep architecture is not importantly affected in BERS but CAP analysis reveals a decrease of NREM instability,
  • the decrease of CAP and of EEG slow oscillations and arousals might be linked with the inhibitory action of spindling activity and spikes on arousals
  • Spike activity and CAP A1 subtypes seem to be mutually exclusive probably because centro-temporal spikes disturb the physiological synchronization mechanisms needed for the generation of slow-wave components of CAP
  • CAP analysis discloses sleep structure abnormalities in children with BERS not shown by the classical sleep scoring
BECT:Benign epilepsy of childhood with centro-temporal spikesもしくはbenign epilepsy with rolandic spikes (BERS)は睡眠構築に異常をきたす。
通常の脳波測定ではわからないが,CAP(cyclic alternating pattern)測定で睡眠構築障害が明かになるのだそうだ。
最近はCAPの自動解析プログラムなんかもあるみたいだし､益々小児の睡眠評価測定では重要な位置を占めることになるんだろう。
Benign epilepsy of childhood with centro-temporal spikesは児童期に頻度が多く、認知機能障害との関連も言われていているので中々興味深い。