14 Apr 2010

What Causes Seizure In Focal Epilepsy?

What Causes Seizure In Focal Epilepsy?
http://www.medicalnewstoday.com/articles/185382.php
部分てんかんの発症メカニズムの鍵はアストロサイトが握っている
  • a key question remains unanswered: what are the earliest cellular events leading to the initiation of a focal seizure?
  • early activation of astroglia, the main population of glial cells in the brain, by hyperactive neurons is one of the crucial events that predisposes neurons nearby to the generation of an epileptic discharge.
  • Epileptic discharge, in turn, triggers a second activation of astrocytes that may favour seizure propagation.

    a recurrent excitatory loop between neurons and astrocytes developing at restricted brain sites promotes and sustains epileptic seizures

てんかん もまだまだ細胞レベルでは分かっていないことが多い。アストログリアがどういうきっかけで異常興奮をきたすのかな?